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January 16, 2018
New study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging looks at the effects of heavy cannabis use on brain function and behavior
Young people with cannabis dependence have altered brain function that may be the source of emotional disturbances and increased psychosis risk that are associated with cannabis abuse, according to a new study published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. The alterations were most pronounced in people who started using cannabis at a young age. The findings reveal potential negative long-term effects of heavy cannabis use on brain function and behavior, which remain largely unknown despite the drug's wide use and efforts to legalize the substance.
"These brain imaging data provide a link between changes in brain systems involved in reward and psychopathology and chronic cannabis abuse, suggesting a mechanism by which heavy use of this popular drug may lead to depression and other even more severe forms of mental illness," said Dr. Cameron Carter, Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.
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SARA BRITTANY SOMERSET March 12, 2018
The United Nations International Narcotics Control Board (INCB) recently issued its 2017 annual report, and the takeaway with regard to cannabis is clear: The INCB is deeply concerned with the spread of adult-use legalization.
Countries pursuing legalization are acting in 'clear violation' of the UN's 1961 Single Convention on Narcotic Drugs, says the International Narcotics Control Board.
The report contains stern warnings, accusing countries like Uruguay of acting in “clear violation” of global drug control accords.
The Board, which monitors compliance with international drug control treaties, is made up of individuals, not U.N. member states. That’s meant to protect it from political pressure. The Board’s charter also stipulates, however, that it must include individuals with “medical, pharmacological or pharmaceutical experience.” That means Big Pharma is well represented, while advocates for cannabis legalization—whether medical or adult-use—have no seat at the table.
International drug control treaties, signed by most member states decades ago, are meant to prohibit the proliferation and non-medical use of dangerous drugs. Cannabis is specifically covered under most of the treaties.
However, in recent years countries like Uruguay have legalized and regulated the non-medical use of cannabis. Canada is planning to legalize later this year. In the United States, nine states and the District of Columbia have implemented some form of adult-use legalization.
That does not sit well with the INCB. “Governments and jurisdictions in North America have continued to pursue policies with respect to the legalization of the use of cannabis for non-medical purposes, in violation of the 1961 Convention as amended,” states the Board’s 2017 report.
Warnings to Uruguay, Jamaica
The Board strongly cautioned Uruguay, which legalized cannabis nationally in 2013, and currently sells cannabis in pharmacies, that the nation is “acting in clear violation” of the drug treaties.
“The limitation of the use of controlled substances to medicinal and scientific purposes is a fundamental principle to which no derogation is permitted under the 1961 Convention as amended,” the INCB report says.
The U.N. board members also criticized Jamaica for legalizing cannabis for religious use three years ago. Cannabis is considered a religious sacrament among adherents of the Rastafarian religion. Rastafarians take their spiritual name from Ras Tafari Makonnen Woldemikael, (Emperor Haile Selassie I, of Ethiopia). Selassie is considered a direct descendent of King Solomon.
While the U.N. claims to promote global religious tolerance, the INCB strongly disagrees with the religious nature of the rasta cannabis ceremony.
“The Board reminds the Government of Jamaica, and all other parties, that under article 4, paragraph (c), of the 1961 Convention as amended, only the medical and scientific use of cannabis is authorized, and that use for any other purposes, including religious, is not permitted,” the report states.
U.N. News – Recreational cannabis poses ‘significant’ health challenges to youth: drugs control body
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The UN-backed International Narcotics Control Board (INCB) warned on Tuesday that poorly regulated medical cannabis programmes could step-up the “recreational” use of the drug while diminishing public concern over its harmful effects.
“Legalization of cannabis for recreational purposes, as seen in a small number of countries, represents not only a challenge to the universal implementation of the treaties and the signatories to the treaties, but also a significant challenge to health and wellbeing, particularly among young people”, INCB President Viroj Sumyai said, following the publication of the body’s latest Annual Report.
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In Amsterdam and London, specifically, there was a strong tie between the use of high-potency cannabis and the presence of psychosis. The researchers linked four in 10 (43.8 percent) new cases of psychosis in Amsterdam to daily cannabis consumption and five out of 10 (50.3 percent) of new cases with the use of highly potent versions of the drug.
In London, the researchers believe they could link 21.0 percent of new cases to daily use and 30.3 percent to a preference for highly potent cannabis.
"Our findings are consistent with previous studies showing that the use of cannabis with a high concentration of THC has more harmful effects on mental health than the use of weaker forms," notes lead study author Dr. Marta Di Forti.
"They also indicate for the first time how cannabis use affects the incidence of psychotic disorder at a population level," she adds.
"As the legal status of cannabis changes in many countries and states, and as we consider the medicinal properties of some types of cannabis, it is of vital public health importance that we also consider the potential adverse effects that are associated with daily cannabis use, especially high potency varieties."
Dr. Marta Di Forti
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JAMA Psychiatry. 2019;76(7):762-764. doi:10.1001/jamapsychiatry.2019.0076
Mirroring increases in the general population, the prevalence of past-month marijuana use among pregnant mothers in the United States increased by 75% between 2002 (2.85%) and 2016 (4.98%).1 Although cannabis use has been linked to psychosis, little is known about prenatal exposure.2,3 Unprecedented increases in marijuana use during pregnancy, alongside evidence that cannabis use is correlated with psychosis and that endocannabinoids play an important role in neurodevelopment, highlight the importance of evaluating potential long-term consequences of prenatal exposure.4
Thus, prenatal cannabis exposure may be associated with later psychosis proneness in offspring. Only when there is sufficient fetal endocannabinoid type 1 receptor expression, which may not occur until after many mothers learn they are pregnant. In the context of increasing cannabis accessibility and potency, perceptions of safety, and the potential use of cannabis to combat pregnancy-related nausea, these data suggest that cannabis use by pregnant women should be discouraged until more is known.
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- Associations of Parental Marijuana Use With Offspring Marijuana, Tobacco, and Alcohol Use and Opioid Misuse
- Cannabis really is a gateway drug that leads users on to harder illegal substances like cocaine by making users more sensitive to its effects
- Broad Spectrum epidemiological contribution of cannabis and other substances to the teratological profile of northern New South Wales-BMC2020