Get a Clue - Weed

Details: Published: 04 June 2023; Hits: 1184

JAMA Psychiatry. Published online May 24, 2023.

Question: Is cannabis use disorder associated with an increased risk of psychotic and nonpsychotic unipolar depression and bipolar disorder?

Findings: In this cohort study of 6 651 765 individuals in Demark, cannabis use disorder was associated with an increased risk of both psychotic and nonpsychotic unipolar depression and bipolar disorder.

Meaning: The findings suggest that cannabis use disorder is independently associated with bipolar disorder and unipolar depression.

Importance: Cannabis use is increasing worldwide and is suspected to be associated with increased risk of psychiatric disorders; however, the association with affective disorders has been insufficiently studied.

Results: A total of 6 651 765 individuals (50.3% female) were followed up for 119 526 786 person-years. Cannabis use disorder was associated with an increased risk of unipolar depression (HR, 1.84; 95% CI, 1.78-1.90), psychotic unipolar depression (HR, 1.97; 95% CI, 1.73-2.25), and nonpsychotic unipolar depression (HR, 1.83; 95% CI, 1.77-1.89). Cannabis use was associated with an increased risk of bipolar disorder in men (HR, 2.96; 95% CI, 2.73-3.21) and women (HR, 2.54; 95% CI, 2.31-2.80), psychotic bipolar disorder (HR, 4.05; 95% CI, 3.52-4.65), and nonpsychotic bipolar disorder in men (HR, 2.96; 95% CI, 2.73-3.21) and women (HR, 2.60; 95% CI, 2.36-2.85). Cannabis use disorder was associated with higher risk for psychotic than nonpsychotic subtypes of bipolar disorder (relative HR, 1.48; 95% CI, 1.21-1.81) but not unipolar depression (relative HR, 1.08; 95% CI, 0.92-1.27).

Conclusions and Relevance: This population-based cohort study found that CUD was associated with an increased risk of psychotic and nonpsychotic bipolar disorder and unipolar depression. These findings may inform policies regarding the legal status and control of cannabis use.

(Source: https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2804862 )

Details: Published: 19 May 2023; Hits: 903

Objective: To examine whether timing of in utero marijuana exposure independently and negatively impacts fetal growth, and if these effects are global or specific to certain growth parameters

Conclusions: Timing of marijuana exposure appears to play a key role in specific fetal growth deficits, with exposure throughout gestation most detrimental. However even first trimester exposure may result in decreased weight.

(Source: (PDF) (researchgate.net)

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Details: Published: 19 May 2023; Hits: 1231

Spain’s Universities of Leon and Oviedo found that “The gateway hypothesis holds that cannabis use increases other illegal substance use. Cannabis use duplicated the probabilities of tobacco and alcohol use.

Cannabis use increased 5 times the likelihood of use of other illegal drugs”.

Testing the cannabis gateway hypothesis in a national sample of Spanish adolescents

Highlights

The gateway hypothesis holds that cannabis use increases other illegal substance use.
Cannabis use duplicated the probabilities of tobacco and alcohol use.
Cannabis use increased five times the likelihood of use of other illegal drugs.

Source https://www.sciencedirect.com/science/article/pii/S0306460323001466

Also see Cannabis and the Gateway Drug Theory: Correlation or Causation – Where does the Evidence Point?(DRR)

Details: Published: 19 May 2023; Hits: 954

The toxicological profile of CBD raises safety concerns, especially for long term consumption by the general population.

Highlights

Potential hazards from long term oral use of CBD are discussed.
CBD-induced male reproductive toxicity is observed from invertebrates to primates.
Mechanisms of CBD-mediated oral toxicity are not fully understood.

for full Research

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Details: Published: 17 May 2023; Hits: 969

Abstract: The legalization of recreational and medical cannabis has increased the availability and potency of cannabis products in homes and communities. Although state laws regarding legalization and commercial sale often encompass adult use only, pediatric toxicity from unintentional exposures to cannabis edibles and adolescent harm from chronic use are increasing in states and countries that have relaxed laws on use. Unintentional edible ingestions are shown to increase in regions that legalize and commercialize cannabis products at the retail level. Long-term effects on teenagers regarding psychiatric changes as well as acute gastrointestinal effects from hyperemesis syndrome are well documented in the medical literature... [Pediatr Ann. 2023;52(5):e181-e186.] (Source: https://pubmed.ncbi.nlm.nih.gov/37159059/ )

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