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JAMA Netw Open. 2020;3(4):e202370. doi:10.1001/jamanetworkopen.2020.2370
Findings In this meta-analysis of observational studies including 23 518 participants, the prevalence of cannabis withdrawal syndrome was found to be 47%. Factors that were associated with higher cannabis withdrawal syndrome were clinical settings (particularly inpatient and outpatient vs population settings), concurrent tobacco or other substance use, and daily cannabis use.
Meaning Cannabis withdrawal syndrome appears to be common among regular users of cannabis, particularly those in outpatient and inpatient settings and individuals with substance use disorders; clinicians should be aware of the high prevalence of cannabis withdrawal syndrome to counsel patients and support individuals who are reducing their use of cannabis.
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A recent study in which rats could self-administer cannabis vapor may provide a useful research model for humans.
The study’s most significant finding was that the ingestion of cannabis resulted in drug-seeking behavior not unlike that common in human users of cannabis.
Another significant observation describes some familiar behavior the rats exhibited after receiving the cannabis vapor.
The rats consumed more food while under the influence, a phenomenon reminiscent of human “munchies,” and their activity levels were lower than they would normally be. Even so, they burned more calories than either of the other groups.
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Female eggs exposed to THC, the psychoactive ingredient in marijuana, have an impaired ability to produce viable embryos, and are significantly less likely to result in a viable pregnancy, according to an animal study accepted for presentation at ENDO 2020, the Endocrine Society's annual meeting… The eggs' developmental rates and gene expression were measured. The researchers evaluated the ability of embryos to reach critical stages of development at specific time points. With higher concentrations of THC, they found a significant decrease and delay in the ability of the treated oocytes to reach these checkpoints.
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