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Methamphetamine – the Respiratory System & Covid-19: Bad Combination

 

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The Substance Abuse and Mental Health Services Administration
(SAMHSA) is the agency within the U.S. Department of Health and Human Services that leads public health efforts to advance the behavioral health of the nation. SAMHSA's mission is to reduce the impact of substance abuse and mental illness on America's communities.

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Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence (springer.com)

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Nitrite ‘Poppers’: Here’s Why FDA Warned Against Their Use For Fun, Sex

Nitrite “poppers” are not the same as chicken poppers, pizza poppers, or cheesy corn poppers. While you can still use the latter three for recreation or sexual enhancement, the U.S. Food and Drug Administration (FDA) is warning that you should not use nitrite “poppers” for such purposes. That’s because nitrite “poppers” can lead to all sorts of bad health effects, including death. And death, for most people, is not good for sex.

Relaxing your smooth muscles with “poppers” can be hazardous though. After all, your body is more than just your anus or vagina. Dropping your blood pressure can mean that different parts of your body may not get enough blood and oxygen. Alkyl nitrites can lead to methemoglobinemia too. This is where your body produces an abnormal amount of methemoglobin. Methemoglobin is a form of hemoglobin. Hemoglobin is the protein in red blood cells (RBCs) that normally picks up oxygen from your lungs, carries it via the bloodstream, and then releases the oxygen to your body tissues. The problem is the methemoglobin form of hemoglobin, in the words of Mariah Carey, can’t let go. It can’t really release the oxygen to your body tissues, effectively starving these tissues of oxygen.

Therefore, it’s not a complete surprise that the FDA has, in their words, “observed an increase in reports of deaths and hospitalizations with issues such as severe headaches, dizziness, increase in body temperature, difficulty breathing, extreme drops in blood pressure, blood oxygen issues (methemoglobinemia) and brain death after ingestion or inhalation of nitrite ‘poppers.’” Death will, of course, really relax your anus and vagina but has other consequences.

The risk of bad effects jumps even higher when you combine poppers with other substances that can also dilate your blood vessels. These substances include blood pressure medications, sildenafil (Viagra), and alcohol. But, of course, no one mixes alcohol or Viagra with sex, right?

The FDA warned specifically about using nitrite “poppers” for recreational purposes or sexual enhancement.

For more

Also see Truth About Poppers


World Drug Day 2021: Get the Facts for Your Healthy Life and Community

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What are magic mushrooms and psilocybin?

 Psilocybin is a hallucinogenic substance people ingest from certain types of mushrooms that grow in regions of Europe, South America, Mexico, and the United States.

Risks

People who have taken psilocybin in uncontrolled settings might engage in reckless behavior, such as driving while intoxicated.

Some people may experience persistent, distressing alterations to the way they see the world. These effects are often visual and can last anywhere from weeks to years after using the hallucinogen.

Physicians now diagnose this condition as hallucinogen persisting perception disorder, also known as a flashback. A flashback is a traumatic recall of an intensely upsetting experience. The recollection of this upsetting experience during hallucinogen use would be a bad trip, or a hallucination that takes a disturbing turn.

Some individuals experience more unpleasant effects than hallucinations, such as fear, agitation, confusion, delirium, psychosis, and syndromes that resemble schizophrenia, requiring a trip to the emergency room.

In most cases, a doctor will treat these effects with medication, such as benzodiazepines. These effects often resolve in 6 to 8 hours as the effects of the drug wear off.

Finally, though the risk is small, some psilocybin users risk accidental poisoning from eating a poisonous mushroom by mistake – Symptoms of mushroom poisoning may include muscle spasms, confusion, and delirium. Visit an emergency room immediately if these symptoms occur.

Because hallucinogenic and other poisonous mushrooms are common to most living environments, a person should regularly remove all mushrooms from areas where children are routinely present to prevent accidental consumption.

Most accidental mushroom ingestion results in minor gastrointestinal illness, with only the most severe instances requiring medical attention.

 

Psilocybin as a treatment for depression

Discussions are ongoing about whether psychological specialists can use psilocybin and similar hallucinogens as a treatment for depression.

Two studies have looked at psilocybin as a treatment. One study examined the ability of psilocybin to reduce depression symptoms without dulling emotions, and the other assessed the relationshipTrusted Source between any positive therapeutic outcomes and the nature of psilocybin-induced hallucinations.

While some researchers are looking into some therapeutic uses for psilocybin, they still, at present, regard psilocybin as unsafe and illegal.

Effects

The effects of psilocybin are generally similar to those of LSD. They include an altered perception of time and space and intense changes in mood and feeling.

Possible effects of psilocybin include:

  • quickly changing emotions
  • derealization, or the feeling that surroundings are not real
  • depersonalization, or a dream-like sense of being disengaged from surroundings
  • euphoria
  • distorted thinking
  • visual alteration and distortion, such as halos of light and vivid colors
  • dilated pupils
  • dizziness
  • drowsiness
  • peacefulness
  • impaired concentration
  • muscle weakness
  • lack of coordination
  • unusual body sensations
  • nausea
  • paranoia
  • confusion
  • ‘spiritual’ awakening
  • frightening hallucinations
  • vomiting
  • yawning

For complete article


World Drug Report 2020 (Exective Summary) UNODC

For all reports go to World Drug Report 2020 (unodc.org)

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UNODC – Strategy 2021-25 (United Nations Office Drugs & Crime)


Students Who Turn To Adderall To Cram For Tests May Be Hurting Their Developing Brain

Easy A’s Now Means Struggles Down The Road

A common belief among students is that taking their friend’s Adderall will help them stay awake and be able to retain information better, but studies on academic performance and Adderall find there is no proof of benefit when used that way.

Conversely, they are damaging the prefrontal cortex, the part of the brain that stores long-term memories, according to Begdache, who began researching Adderall abuse in 2009 when a student asked her about it. She said the brain does not fully develop until age 25, and most college students are between the ages of 18 and 24. 

But the dangers don’t end there. Adderall abuse can affect a person’s mood, leading to short-term side effects like paranoia, insomnia and anger.  Continuing to abuse the drug can lead to dependency on other drugs such as THC (the chemical in marijuana) and alcohol. Dependency may become so severe that one could not perform daily responsibilities without it.

“When someone consumes unprescribed medications, it can place them at risk for adverse reactions.  There can also be risks with consuming counterfeit pills that have been adulterated,” said Kelly Truesdell, assistant director of health promotion and community outreach at the University of Georgia.

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What Parents Need Know About Weed - AALM flyer

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Ecstasy Deaths – Red Card on Pill Testing

Ecstasy Deaths – Red Card on Pill Testing


DRUGS OF ABUSE 2020 Guide

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 Concerns About CBD?

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Pill Testing Increases Festival Goers Intention to Use Ecstasy.

Conclusion – Based on the evaluation, pill testing represents a real and present danger to the community, especially considering that generally, those who reported moderate levels of intention to use a drug before entering the pill testing service, increased their intention to use a drug after using the pill testing service. This is the exact opposite to what our Members of Parliament, the community and the media have been led to believe. Mr. Waterman said, this is absolutely damning evidence and confirms what I have said from the start, Pill testing normalises drug use and will likely lead to an increase in drug use as a result.

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The Key Role of Epigenetics in Human Disease Prevention and Mitigation

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‘Alarming’ amount of new drugs on dark web: ANU study

Australians have access to mass amounts of potent drugs online, equivalent to "billions of doses" every day, according to a new study from The Australian National University (ANU).

The report found "alarming" amounts of synthetic opioids such as fentanyl and carfentanil available on the dark web. 

Carfentanil is not for human use and was originally designed to sedate elephants. 

The researchers say the report lifts the lid on a significant new synthetic opioid market on the dark web. 

"We are on the brink of a new opioid epidemic driven by synthetics like fentanyl and carfentanil that are driving a greater risk of overdose deaths," said lead author Professor Roderic Broadhurst, from the ANU Cybercrime Observatory.

"Fentanyl is a designer synthetic opioid about 100 times more powerful than morphine," said Professor Broadhurst.

"The average dose of fentanyl is 200 micrograms. We found millions of doses of fentanyl available to buy every day.

"Carfentanil is 10,000 times more powerful than morphine and there are alarming amounts of it available online." 

"We were shocked by the amount of Carfentanil we found. Billions of doses are available online on any day." 

Professor Broadhurst says fentanyl is being used by criminal networks to lace heroin and create synthetic heroin that is changing the landscape of narcotic sales.

For complete story

 

Measuring Aerosol Particle Emissions from Cannabis Vaporization and Dabbing

SUMMARY 

Cannabis smoke contains many of the same carcinogens and chemicals found in tobacco smoke (Moir, Rickert et al. 2008, Wei, Alwis et al. 2016). Exposure to secondhand cannabis smoke can impair endothelial function, which increases the risk of cardiovascular disease (Wang, Derakhshandeh et al. 2016). However, US data show that the perceived health risks of marijuana use are, in fact, declining among adults (Compton, Han et al. 2016). We measured the concentrations of airborne fine particles (PM2.5) and cannabinoids at an indoor cannabis event where dabbing and vaporizing were the only cannabis emissions. We found average particle concentrations of 200-600 micrograms per m3 and peak concentrations over 1,600 micrograms per m3. Particle concentrations this high are seen in extreme air pollution events like wildfires (Landis, Edgerton et al. 2018, Li, Han et al. 2018) and severe industrial pollution (Nagar, Singh et al. 2017, Li, Han et al. 2018). Exposure at these concentrations can cause cardiovascular and respiratory disease (Zheng, Ding et al. 2015, Li, Fan et al. 2016). We show that dabbing and vaporizing cannabis can create levels of indoor air pollution that are hazardous to human health, in the absence of actual combustion. 

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VAPING IS DESIGNED TO APPEAL TO KIDS: 

Flavors are chosen that entice young appetites, like cookies & cream, cups o’ peanut butter and bubble gum. Stanford University compiled a startling gallery of photos comparing actual vape products to their sugar-coated candy and dessert inspirations.

Regardless of how they are ingested, nicotine and THC hurt kids’ developing brains. Vaping can provide very high concentrations of these drugs.  For example, one JUUL pod has as much nicotine as a pack of cigarettes.

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Vaping 'can damage vital immune system cells'

August 2018

Vaping can damage vital immune system cells and may be more harmful than previously thought, a study suggests.

Researchers found e-cigarette vapour disabled important immune cells in the lung and boosted inflammation. The researchers "caution against the widely held opinion that e-cigarettes are safe".

However, Public Health England advises they are much less harmful than smoking and people should not hesitate to use them as an aid to giving up cigarettes. The small experimental study, led by Prof David Thickett, at the University of Birmingham, is published online in the journal Thorax.

For complete article

 

Carfentanil

Similar to other fentanils, the most serious acute health risk from using carfentanil is likely to be rapid and severe respiratory depression, which in overdose could lead to apnoea, respiratory arrest, and death (Dahan et al., 2010; EMCDDA, 2017; Lindsay et al., 2016; Pattinson, 2008; Wax et al., 2003; White and Irvine, 1999). Factors that may exacerbate this risk include: the difficulty in diluting the substance, which can lead to a toxic dose being inadvertently used; the use of routes of administration that have high bioavailability (such as injecting, insufflation, and inhalation); a lack of experience with its effects and dosing; the use of other central nervous system depressants at the same time (such as other opioids, benzodiazepines, gabapentanoids, and alcohol); no or limited tolerance to opioids; and, using the substance alone (such as at home) which would make it more difficult for users to call for help in the case of poisoning. In addition, as discussed below, as carfentanil is being sold as or in heroin and other illicit opioids, many users will not be aware that they are using carfentanil. 

Complete report see attached PDF

 

The Global SMART

(Synthetics Monitoring: Analyses, Reporting and Trends)

Programme improves the capacity of targeted Member States to generate, manage,   analyse, report and use information on illicit synthetic drugs.  The SMART programme was launched in September 2008 in Bangkok.

For more information go to

 

Pill Testing may sound like a compassionate option...
but what really happens?

SCORING PILL TESTING

 

Well, if you're here reading this, you've at least had enough moxy in ya to start trying to 'get a clue'!

We know 'data' alone doesn't change behaviour, but at least it's a 'wake up' for those who give a damn – and you obviously do! The information in these 'Dalgarnowledge' sheets is up to date and accurate. They give a little more than mere 'facts' but the data integrity is not compromised….so read, learn, act and change!

See you again soon!

Listing of Information PDF Files

For a range of FACT Sheets on various Cannabis Use Related issues go to NCPIC https://cannabissupport.com.au/

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