Although vaping is relatively new and studies are limited, some research suggests that it may worsen GERD symptoms. Nicotine and other chemicals in e-cigarettes may cause inflammation and affect the function of the valve that prevents stomach acid from rising into the esophagus. The authors suggest that vaping may cause mucosal injury, oxidative stress, and DNA damage. In addition, they note that the inconsistent regulation of e-cigarettes can result in people inhaling unknown chemicals and toxins.
What is the relationship between vaping and GERD? (medicalnewstoday.com)