Combining MDMA and alcohol increases the risk of adverse or severe side effects. In some cases, side effects can be fatal or cause long-term health problems. Taking both MDMA and alcohol increases the risk of an acute intoxication and accompanying harms. If people think someone has consumed MDMA or too much alcohol or both, they should seek immediate medical help. All use of psychotropic toxins carries risk, both short and long term. No use is best health practice.