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Moderate alcohol use is associated with neuronal changes in both males and females suggesting health risks that should not be overlooked. We found a direct association between moderate alcohol consumption and decreased brain volume at early middle-age in both males and females. Understanding of the mechanisms of moderate drinking on the brain is incomplete, but even moderate alcohol consumption may have a harmful effect already in middle-age. Recent systematic analysis on alcohol use and global disease burden suggests that the level of consumption that minimizes health loss is zero 31. The risk that even moderate drinking poses on the brain should not be overlooked

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